Synthesis of some novel chalcones, flavanones and flavones and evaluation of their anti-inflammatory activity

Abstract

A novel series of synthetic 2′-hydroxychalcones (1a-h), 2′-methoxychalcones (2a-l), flavanones (3a-k) and flavones (4a-f) have been synthesized and evaluated for their anti-inflammatory activity in carrageenan induced rat paw oedema model. Compounds 1a, 1e-g, 2e-g, 3j, and 4f showed potent antiinflammatory activity comparable to the reference drug indomethacin with insignificant ulceration. Compound 1f showed mild inhibition against the enzymatic activity of ovine COX-1 and COX-2 (in-vitro). Compound 1f also exhibited inhibitory activity in LPS induced TNF-α production. © 2013 Elsevier Masson SAS. All rights reserved.