A convenient method for the preparation of oxazaborolidine catalyst in situ using (S)-α,α-diphenylpyrrolidinemethanol, tetrabutylammonium borohydride, and methyl iodide for the asymmetric reduction of prochiral ketones

dc.contributor.author Anwar, Shaik
dc.contributor.author Periasamy, Mariappan
dc.date.accessioned 2022-03-27T09:08:17Z
dc.date.available 2022-03-27T09:08:17Z
dc.date.issued 2006-12-11
dc.description.abstract An oxazaborolidine catalyst is readily prepared in situ at 25 °C in THF using (S)-α,α-diphenylpyrrolidinemethanol and borane generated from tetrabutylammonium borohydride/CH3I reagent system. The oxazaborolidine/BH3 reagent system prepared in this way is useful for the reduction of prochiral ketones to the corresponding alcohols with up to 99% ee. © 2006 Elsevier Ltd. All rights reserved.
dc.identifier.citation Tetrahedron Asymmetry. v.17(23)
dc.identifier.issn 09574166
dc.identifier.uri 10.1016/j.tetasy.2006.11.032
dc.identifier.uri https://www.sciencedirect.com/science/article/abs/pii/S0957416606008652
dc.identifier.uri https://dspace.uohyd.ac.in/handle/1/12475
dc.title A convenient method for the preparation of oxazaborolidine catalyst in situ using (S)-α,α-diphenylpyrrolidinemethanol, tetrabutylammonium borohydride, and methyl iodide for the asymmetric reduction of prochiral ketones
dc.type Journal. Article
dspace.entity.type
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