Convenient methods to access chiral camphanyl amine derivatives by sodium borohydride reduction of d -(-)-camphorquinone imines

Abstract

d-(-)-Camphorquinone imines prepared using methanolic ammonia, ethanol amine, exo-(-)-bornylamine, ethylene diamine, propylene diamine, and trans-(R,R)-1,2-diaminocyclohexane, upon reduction using sodium borohydride in methanol, give the corresponding chiral exo amino alcohol and diamine derivatives in good yields (75-95%). © 2012 Georg Thieme Verlag Stuttgart New York.