In situ formed acetals facilitated direct Michael addition of unactivated ketones
In situ formed acetals facilitated direct Michael addition of unactivated ketones
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Date
2017-01-01
Authors
Koppolu, Srinivasa Rao
Balamurugan, Rengarajan
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Abstract
TfOH-promoted synthesis of 1,5-diketones by the Michael reaction of unactivated ketones with chalcones has been described. Acetals formed under HC(OMe)3/TfOH conditions generate the required enol-equivalents for a smooth Michael reaction. A wide array of symmetrical and unsymmetrical 1,5-diketones has been synthesised.
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New Journal of Chemistry. v.41(3)