Synthesis of substituted maleimide derivatives using the Baylis-Hillman adducts
Synthesis of substituted maleimide derivatives using the Baylis-Hillman adducts
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Date
2011-10-10
Authors
Basavaiah, Deevi
Lenin, Dandamudi V.
Veeraraghavaiah, Gorre
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Journal ISSN
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Abstract
The Baylis-Hillman alcohols, 3-ethoxycarbonyl-3-hydroxy-3-aryl(alkyl)-2-methylenepropanenitriles, derived from α-keto esters and acrylonitrile, have been conveniently transformed into 3,4-disubstituted 1Hpyrrole-2,5-dione (maleimide) derivatives on treatment with FeCl 3/RCO 2H in a one-pot operation.
Description
Keywords
α-Keto esters,
Baylis-Hillman adducts,
Cyclization,
Friedel-Crafts reaction,
Pyrrole-2,5-diones
Citation
Current Science. v.101(7)