Double cascade reactions based on the Barbas dienamine platform: Highly stereoselective synthesis of functionalized cyclohexanes for cardiovascular agents

dc.contributor.author	Ramachary, Dhevalapally B.
dc.contributor.author	Reddy, Y. Vijayendar
dc.contributor.author	Prakash, B. Veda
dc.date.accessioned	2022-03-27T09:41:44Z
dc.date.available	2022-03-27T09:41:44Z
dc.date.issued	2008-01-01
dc.description.abstract	The amino acid proline catalyzed the three- and five-component cascade olefination-Diels-Alder-epimerization and olefination-Diels-Alder-epimerization- olefination-hydrogenation reactions of readily available precursors enones 1a-i, arylaldehydes 2a-k, alkyl cyanoacetates 3a-e and Hantzsch ester 9 to furnish highly substituted prochiral 1-cyano-4-oxo-2,6-diaryl-cyclohexanecarboxylic acid alkyl esters 6 and 1-cyano-4-(cyano-alkoxycarbonyl-methyl)-2,6-diaryl- cyclohexanecarboxylic acid alkyl esters 10 in a highly diastereoselective fashion with excellent yields. Prochiral cis-isomers 6 are excellent starting materials for the synthesis of cardiovascular agents and hypnotic active products. © The Royal Society of Chemistry 2008.
dc.identifier.citation	Organic and Biomolecular Chemistry. v.6(4)
dc.identifier.issn	14770520
dc.identifier.uri	10.1039/b718122a
dc.identifier.uri	http://xlink.rsc.org/?DOI=b718122a
dc.identifier.uri	https://dspace.uohyd.ac.in/handle/1/13206
dc.title	Double cascade reactions based on the Barbas dienamine platform: Highly stereoselective synthesis of functionalized cyclohexanes for cardiovascular agents
dc.type	Journal. Article
dspace.entity.type

Now showing 1 - 1 of 1