Organocatalytic asymmetric domino Knoevenagel/Diels-Alder reactions: A bioorganic approach to the diastereospecific and enantioselective construction of highly substituted spiro [5,5]undecane-1,5,9-triones

dc.contributor.author	Ramachary, D. B.
dc.contributor.author	Chowdari, Naidu S.
dc.contributor.author	Barbas, Carlos F.
dc.date.accessioned	2022-03-27T09:42:47Z
dc.date.available	2022-03-27T09:42:47Z
dc.date.issued	2003-09-15
dc.description.abstract	A practical and environmentally friendly organocatalytic process for the synthesis of optically active highly substituted spiro[5,5]undecane-1,5,9-triones was achieved through the reaction of an aldehyde, an enone, and Meldrum's acid in the presence of a catalytic amount of chiral amino acid (see scheme). The Diels-Alder products were obtained as single diastereomers in excellent yields and enantiomeric excesses.
dc.identifier.citation	Angewandte Chemie - International Edition. v.42(35)
dc.identifier.issn	14337851
dc.identifier.uri	10.1002/anie.200351916
dc.identifier.uri	https://onlinelibrary.wiley.com/doi/10.1002/anie.200351916
dc.identifier.uri	https://dspace.uohyd.ac.in/handle/1/13225
dc.subject	Amino acids
dc.subject	Asymmetic catalysis
dc.subject	Cycloaddition
dc.subject	Domino reactions
dc.subject	Enantioselectivity
dc.title	Organocatalytic asymmetric domino Knoevenagel/Diels-Alder reactions: A bioorganic approach to the diastereospecific and enantioselective construction of highly substituted spiro [5,5]undecane-1,5,9-triones
dc.type	Journal. Article
dspace.entity.type

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