Stereoselective synthesis of C < inf > 18 < /inf > -guggultetrol and C < inf > 18 < /inf > -phytosphingosine analogues from d-fructose
Stereoselective synthesis of C < inf > 18 < /inf > -guggultetrol and C < inf > 18 < /inf > -phytosphingosine analogues from d-fructose
| dc.contributor.author | Ramu Sridhar, Perali | |
| dc.contributor.author | Suresh, Mandava | |
| dc.contributor.author | Venu Kumar, Patteti | |
| dc.contributor.author | Seshadri, Kalapati | |
| dc.contributor.author | Venkata Rao, Chunduri | |
| dc.date.accessioned | 2022-03-27T08:37:37Z | |
| dc.date.available | 2022-03-27T08:37:37Z | |
| dc.date.issued | 2012-10-01 | |
| dc.description.abstract | A series of C 18-guggultetrol stereo isomers and C 18-phytosphingosine regio/stereo isomers were synthesised in a stereoselective fashion involving metal mediated fragmentation, stereoselective reduction, 1,4 O→O silyl migration, and Grubbs' cross metathesis as key steps. d-Fructose was used as a raw material for the preparation of all the analogues. The isophytosphingosine derivatives were evaluated against their 5-LOX (5-lipoxigenase) inhibitory activity. © 2012 Elsevier Ltd. All rights reserved. | |
| dc.identifier.citation | Carbohydrate Research. v.360 | |
| dc.identifier.issn | 00086215 | |
| dc.identifier.uri | 10.1016/j.carres.2012.07.016 | |
| dc.identifier.uri | https://www.sciencedirect.com/science/article/abs/pii/S0008621512003084 | |
| dc.identifier.uri | https://dspace.uohyd.ac.in/handle/1/11266 | |
| dc.subject | 5-Lipoxigenase | |
| dc.subject | C -Guggultetrol 18 | |
| dc.subject | d-Fructose | |
| dc.subject | Isophytosphingosine | |
| dc.subject | Phytosphingosine | |
| dc.title | Stereoselective synthesis of C < inf > 18 < /inf > -guggultetrol and C < inf > 18 < /inf > -phytosphingosine analogues from d-fructose | |
| dc.type | Journal. Article | |
| dspace.entity.type |
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