Methods of enhancement of reactivity and selectivity of sodium borohydride for applications in organic synthesis

dc.contributor.author	Periasamy, Mariappan
dc.contributor.author	Thirumalaikumar, Muniappan
dc.date.accessioned	2022-03-27T09:09:57Z
dc.date.available	2022-03-27T09:09:57Z
dc.date.issued	2000-09-08
dc.description.abstract	NaBH4 does not reduce carboxylic acids, esters, amides and nitriles under ambient conditions. However, the reactivity of NaBH4 can be enhanced by the addition of certain additives. For example, addition of iodine to NaBH4 in THF provides H3B-THF that is useful for hydroborations and reductions of various functional groups. The aldehydes and ketones are reduced in a fast manner by the NaBH4 reagent. Even so, the selectivities realised in such reductions can be enhanced using NaBH4 along with another additive. In this article, various methods used for the enhancement of reactivity and selectivity of NaBH4 in organic synthesis are described. © 2000 Elsevier Science S.A. All rights reserved.
dc.identifier.citation	Journal of Organometallic Chemistry. v.609(1-2)
dc.identifier.issn	0022328X
dc.identifier.uri	10.1016/S0022-328X(00)00210-2
dc.identifier.uri	https://www.sciencedirect.com/science/article/abs/pii/S0022328X00002102
dc.identifier.uri	https://dspace.uohyd.ac.in/handle/1/12520
dc.subject	Additives
dc.subject	Enhancement of reactivity
dc.subject	Reduction of organics
dc.subject	Sodium borohydride
dc.title	Methods of enhancement of reactivity and selectivity of sodium borohydride for applications in organic synthesis
dc.type	Journal. Article
dspace.entity.type

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