The acrylamide moiety as an activated alkene component in the intramolecular Baylis-Hillman reaction: Facile synthesis of functionalized α-methylene lactam and spirolactam frameworks

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dc.contributor.author Basavaiah, Deevi
dc.contributor.author Reddy, Guddeti Chandrashekar
dc.contributor.author Bharadwaj, Kishor Chandra
dc.date.accessioned 2022-03-27T09:01:01Z
dc.date.available 2022-03-27T09:01:01Z
dc.date.issued 2014-02-01
dc.description.abstract A facile strategy for the intramolecular Baylis-Hillman reaction by utilizing an acrylamide moiety as an activated alkene component was developed, which thus provides a convenient protocol for obtaining five-and six-membered α-methylene lactam and spirolactam derivatives. An intramolecular Baylis-Hillman reaction by using an acrylamide moiety as an activated alkene and an aldehyde as the electrophile component is described. Thus, a simple synthetic strategy for obtaining α-methylene (γ-and δ-)lactam and spiro-γ-lactam derivatives is provided. DABCO = 1,4-diazabicyclo[2.2. 2]octane. Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
dc.identifier.citation European Journal of Organic Chemistry. v.2014(6)
dc.identifier.issn 1434193X
dc.identifier.uri 10.1002/ejoc.201301526
dc.identifier.uri https://onlinelibrary.wiley.com/doi/10.1002/ejoc.201301526
dc.identifier.uri https://dspace.uohyd.ac.in/handle/1/12271
dc.subject Baylis-Hillman reaction
dc.subject Lactams
dc.subject Nitrogen heterocycles
dc.subject Spiro compounds
dc.title The acrylamide moiety as an activated alkene component in the intramolecular Baylis-Hillman reaction: Facile synthesis of functionalized α-methylene lactam and spirolactam frameworks
dc.type Journal. Article
dspace.entity.type
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