Synthesis of Highly Functionalized Pyrrolidine Derivatives from Easily Accessible Diethyl (E)-4-Oxohex-2-enedioate

Abstract

The diastereoselective synthesis of highly substituted pyrrolidines has been accomplished using a six-carbon building block bearing carbon atoms with different reactivities. In this reaction, the building block acts a 1,3-dipole and undergoes cyclization with imines formed in situ to give pyrrolidine derivatives.