Synthesis and in vitro anticancer and antitubercular activity of diarylpyrazole ligated dihydropyrimidines possessing lipophilic carbamoyl group

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dc.contributor.author Yadlapalli, Rama Krishna
dc.contributor.author Chourasia, O. P.
dc.contributor.author Vemuri, Kiranmayi
dc.contributor.author Sritharan, Manjula
dc.contributor.author Perali, Ramu Sridhar
dc.date.accessioned 2022-03-27T00:59:08Z
dc.date.available 2022-03-27T00:59:08Z
dc.date.issued 2012-04-15
dc.description.abstract A series of dihydropyrimidine derivatives were synthesized by utilizing Biginelli reaction and evaluated for their in vitro anticancer activity against MCF-7 human breast cancer (HBC) cell line using sulforhodamine B (SRB) assay and antitubercular activity against Mycobacterium tuberculosis (MTB) H 37Rv using Microplate Alamar Blue Assay (MABA). Compounds 13p, 13t were exhibited 70.6% and 63.7% of HBC cell growth inhibition at 10 μM concentration. Interestingly compound 13p was also found to be the most potent in the series against MTB H 37Rv with MIC value of 0.125 μg/mL. © 2012 Elsevier Ltd. All rights reserved.
dc.identifier.citation Bioorganic and Medicinal Chemistry Letters. v.22(8)
dc.identifier.issn 0960894X
dc.identifier.uri 10.1016/j.bmcl.2012.02.101
dc.identifier.uri https://www.sciencedirect.com/science/article/abs/pii/S0960894X12003034
dc.identifier.uri https://dspace.uohyd.ac.in/handle/1/3680
dc.subject 1,3-Diarylpyrazoles
dc.subject Anticancer
dc.subject Antitubercular
dc.subject Dihydropyrimidines
dc.subject Multicomponent Reaction
dc.title Synthesis and in vitro anticancer and antitubercular activity of diarylpyrazole ligated dihydropyrimidines possessing lipophilic carbamoyl group
dc.type Journal. Article
dspace.entity.type
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