Parts-per-Million-Level, Catalytic [3+2]-Annulations for the Asymmetric Synthesis of Methanobenzo[7]annulenes

dc.contributor.author	Thirupathi, Guguloth
dc.contributor.author	Ashok, Etikala
dc.contributor.author	Suresh Kumar, A.
dc.contributor.author	Ramachary, Dhevalapally B.
dc.date.accessioned	2022-03-27T09:36:26Z
dc.date.available	2022-03-27T09:36:26Z
dc.date.issued	2021-12-23
dc.description.abstract	3-Alkyl-lawsones selectively reacted with α-alkyl-nitroethylenes under 500 parts-per-million (ppm) quinine-NH-thiourea-catalysis to furnish the chiral methanobenzo[7]annulenes in up to > 99 % ee with > 20 : 1 dr and TON up to 1820 through tandem Michael/Henry [3+2]-annulations. These asymmetric ppm-level, catalytic tandem [3+2]-annulations would be highly inspirational for the design of many more ppm-level organocatalytic reactions, and at the same time these final molecules are basic skeletons of antibiotics.
dc.identifier.citation	Chemistry - A European Journal. v.27(72)
dc.identifier.issn	09476539
dc.identifier.uri	10.1002/chem.202103254
dc.identifier.uri	https://onlinelibrary.wiley.com/doi/10.1002/chem.202103254
dc.identifier.uri	https://dspace.uohyd.ac.in/handle/1/13107
dc.subject	annulations
dc.subject	antibiotics
dc.subject	asymmetric catalysis
dc.subject	lawsone
dc.subject	ppm-level catalysis
dc.title	Parts-per-Million-Level, Catalytic [3+2]-Annulations for the Asymmetric Synthesis of Methanobenzo[7]annulenes
dc.type	Journal. Article
dspace.entity.type

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