Design, synthesis and biological evaluation of optically pure functionalized spiro[5,5]undecane-1,5,9-triones as HIV-1 inhibitors
Design, synthesis and biological evaluation of optically pure functionalized spiro[5,5]undecane-1,5,9-triones as HIV-1 inhibitors
| dc.contributor.author | Ramachary, Dhevalapally B. | |
| dc.contributor.author | Reddy, Y. Vijayendar | |
| dc.contributor.author | Banerjee, Atoshi | |
| dc.contributor.author | Banerjee, Sharmistha | |
| dc.date.accessioned | 2022-03-27T09:40:19Z | |
| dc.date.available | 2022-03-27T09:40:19Z | |
| dc.date.issued | 2011-11-07 | |
| dc.description.abstract | A single-step amino acid-catalyzed diastereoselective three-component synthesis of optically pure highly functionalized spiro[5,5]undecane-1,5,9- triones preferentially over the four stereoisomers was accomplished in very good yields with > 99% ee/de. Preliminary cell culture-based in vivo screening on these molecules revealed that cis-1aca and cis-1jca are better lead compounds for HIV-1 treatment than the known antiretroviral drug azidothymidine (AZT). © 2011 The Royal Society of Chemistry. | |
| dc.identifier.citation | Organic and Biomolecular Chemistry. v.9(21) | |
| dc.identifier.issn | 14770520 | |
| dc.identifier.uri | 10.1039/c1ob06133j | |
| dc.identifier.uri | http://xlink.rsc.org/?DOI=c1ob06133j | |
| dc.identifier.uri | https://dspace.uohyd.ac.in/handle/1/13180 | |
| dc.title | Design, synthesis and biological evaluation of optically pure functionalized spiro[5,5]undecane-1,5,9-triones as HIV-1 inhibitors | |
| dc.type | Journal. Article | |
| dspace.entity.type |
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