The Baylis-Hillman adducts as valuable source for one-pot multi-step synthesis: A facile synthesis of substituted piperidin-2-ones

Abstract

A facile, convenient, and one-pot multi-step synthesis of substituted piperidin-2-ones from the Baylis - Hillman alcohols derived from various aldehydes and acrylonitrile, involving Johnson - Claisen rearrangement, reduction of an α,β-unsaturated nitrile moiety into the saturated amine-skeleton, followed by cyclization, in an operationally simple procedure, is described. © 2010 Verlag Helvetica Chimica Acta AG.