Copper(I) halide promoted diastereoselective synthesis of chiral propargylamines and chiral allenes using 2-dialkylaminomethylpyrrolidine, aldehydes, and 1-alkynes

dc.contributor.author	Gurubrahamam, Ramani
dc.contributor.author	Periasamy, Mariappan
dc.date.accessioned	2022-03-27T09:07:06Z
dc.date.available	2022-03-27T09:07:06Z
dc.date.issued	2013-02-15
dc.description.abstract	Copper bromide promoted reactions of aldehydes, 1-alkynes, and chiral 2-dialkylaminomethylpyrrolidine at 25 C give the corresponding chiral propargylamine derivatives in up to 96% yield and 99:1 dr that are readily converted to the corresponding disubstitued chiral allenes in up to 81% yield and 99% ee upon reaction with CuI in dioxane at 100 C. © 2013 American Chemical Society.
dc.identifier.citation	Journal of Organic Chemistry. v.78(4)
dc.identifier.issn	00223263
dc.identifier.uri	10.1021/jo302534f
dc.identifier.uri	https://pubs.acs.org/doi/10.1021/jo302534f
dc.identifier.uri	https://dspace.uohyd.ac.in/handle/1/12443
dc.title	Copper(I) halide promoted diastereoselective synthesis of chiral propargylamines and chiral allenes using 2-dialkylaminomethylpyrrolidine, aldehydes, and 1-alkynes
dc.type	Journal. Article
dspace.entity.type

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