Chiral pool approach to the total synthesis of phomonol
Chiral pool approach to the total synthesis of phomonol
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Date
2022-01-01
Authors
Dada, Ravikrishna
Yaragorla, Srinivasarao
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Abstract
We report a stereoselective total synthesis of a natural product, phomonol, from readily available D-aspartic acid. The key steps include Wittig olefination, Sharpless asymmetric dihydroxylation, Grignard addition, diastereoselective reductive etherification and Wacker oxidation.
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Keywords
hiral pool,
natural products,
reductive etherification,
sharpless asymmetric dihydroxylation,
Total synthesis
Citation
Synthetic Communications