Direct amino acid-catalyzed asymmetric desymmetrization of meso-compounds: Tandem aminoxylation/O-N bond heterolysis reactions

dc.contributor.author	Ramachary, Dhevalapally B.
dc.contributor.author	Barbas, Carlos F.
dc.date.accessioned	2022-03-27T09:42:30Z
dc.date.available	2022-03-27T09:42:30Z
dc.date.issued	2005-04-14
dc.description.abstract	(Chemical Equation Presented) A practical organocatalytic process for the synthesis of optically active, highly substituted α-hydroxy-ketones was achieved through asymmetric desymmetrization (ADS) of prochiral ketones. The ADS and O-N bond reduction reaction of prochiral ketone with nitrosobenzene in the presence of a catalytic amount of chiral amine or amino acid produced the tandem ADS/O-N bond reduced products as single diastereomers with good yields and excellent enantiomeric excesses. © 2005 American Chemical Society.
dc.identifier.citation	Organic Letters. v.7(8)
dc.identifier.issn	15237060
dc.identifier.uri	10.1021/ol050246e
dc.identifier.uri	https://pubs.acs.org/doi/10.1021/ol050246e
dc.identifier.uri	https://dspace.uohyd.ac.in/handle/1/13220
dc.title	Direct amino acid-catalyzed asymmetric desymmetrization of meso-compounds: Tandem aminoxylation/O-N bond heterolysis reactions
dc.type	Journal. Article
dspace.entity.type

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