Human coronavirus spike protein-host receptor recognition

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dc.contributor.author Guruprasad, Lalitha
dc.date.accessioned 2022-03-27T08:33:47Z
dc.date.available 2022-03-27T08:33:47Z
dc.date.issued 2021-05-01
dc.description.abstract A variety of coronaviruses (CoVs) have infected humans and caused mild to severe respiratory diseases that could result in mortality. The human CoVs (HCoVs) belong to the genera of α- and β-CoVs that originate in rodents and bats and are transmitted to humans via zoonotic contacts. The binding of viral spike proteins to the host cell receptors is essential for mediating fusion of viral and host cell membranes to cause infection. The SARS-CoV-2 originated in bats (RaTG13 SARS-CoV) and is transmitted to humans via pangolins. The presence of 'PRRA' sequence motif in SARS-CoV-2 spike proteins from human, dog, cat, mink, tiger and lion suggests a common viral entry mechanism into host cells. In this review, we discuss structural features of HCoV spike proteins and recognition of host protein and carbohydrate receptors.
dc.identifier.citation Progress in Biophysics and Molecular Biology. v.161
dc.identifier.issn 00796107
dc.identifier.uri 10.1016/j.pbiomolbio.2020.10.006
dc.identifier.uri https://www.sciencedirect.com/science/article/abs/pii/S0079610720301103
dc.identifier.uri https://dspace.uohyd.ac.in/handle/1/10794
dc.subject Amino peptidase N
dc.subject Angiotensin-converting enzyme 2
dc.subject Dipeptidyl peptidase 4
dc.subject HCoV-229E
dc.subject HCoV-HKU1
dc.subject HCoV-NL63
dc.subject HCoV-OC43
dc.subject Human coronavirus
dc.subject MERS-CoV
dc.subject Receptor binding domain
dc.subject SARS-CoV
dc.subject SARS-CoV-2
dc.subject Sialic acid
dc.subject Spike protein
dc.title Human coronavirus spike protein-host receptor recognition
dc.type Journal. Review
dspace.entity.type
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