LiCl regulates mitochondrial biogenesis during megakaryocyte development

dc.contributor.author	Undi, Ram Babu
dc.contributor.author	Gutti, Usha
dc.contributor.author	Gutti, Ravi Kumar
dc.date.accessioned	2022-03-27T04:52:26Z
dc.date.available	2022-03-27T04:52:26Z
dc.date.issued	2017-01-01
dc.description.abstract	JAK-STAT, PI3K-AKT and MAPK signaling pathways are involved in platelet production process. Although wnt signaling has been reported in the biogenesis of platelets, but its role in megakaryocyte development is not well studied. We used an inducible canonical wnt signaling system that utilizes LiCl (GSK-3β inhibitor). LiCl could activate wnt signaling pathway along with maturation of megakaryocytes. Mitochondrial staining showed an increase in mitochondrial mass upon induction with LiCl. Also, mitochondrial markers PGC-1α and TFAM were up regulated with increase in mitochondrial DNA content. LiCl leads to increase in the ROS production, suggesting significance of mitochondria in megakaryocyte development.
dc.identifier.citation	Journal of Trace Elements in Medicine and Biology. v.39
dc.identifier.issn	0946672X
dc.identifier.uri	10.1016/j.jtemb.2016.10.003
dc.identifier.uri	https://www.sciencedirect.com/science/article/abs/pii/S0946672X16303170
dc.identifier.uri	https://dspace.uohyd.ac.in/handle/1/7382
dc.subject	LiCl
dc.subject	Megakaryocyte
dc.subject	Mitochondria
dc.subject	Wnt signaling
dc.title	LiCl regulates mitochondrial biogenesis during megakaryocyte development
dc.type	Journal. Article
dspace.entity.type

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