Synthesis of 1,3-diazetidin-2-ones (aza-β-lactams) as rationally designed transpeptidase and β-lactamase inhibitors
Synthesis of 1,3-diazetidin-2-ones (aza-β-lactams) as rationally designed transpeptidase and β-lactamase inhibitors
| dc.contributor.author | Nangia, A. | |
| dc.contributor.author | Chandrakala, P. S. | |
| dc.date.accessioned | 2022-03-27T09:35:46Z | |
| dc.date.available | 2022-03-27T09:35:46Z | |
| dc.date.issued | 1995-10-16 | |
| dc.description.abstract | Pyrimidinone 4 is converted to diazetidinone carboxaldehyde 6. Selective chemical transformations on tricarbonyl substrate 6 with different reagents are performed. Synthon 6 is employed as a versatile template for elaboration to bicyclic diazetidinones 7, 12 and 15. A novel class of aza-β-lactam compounds are synthesised as potential transpeptidase and β-lactamase inhibitors. © 1995 Pergamon Elsevier Science Ltd. | |
| dc.identifier.citation | Tetrahedron Letters. v.36(42) | |
| dc.identifier.issn | 00404039 | |
| dc.identifier.uri | 10.1016/0040-4039(95)01473-U | |
| dc.identifier.uri | https://www.sciencedirect.com/science/article/abs/pii/004040399501473U | |
| dc.identifier.uri | https://dspace.uohyd.ac.in/handle/1/13094 | |
| dc.title | Synthesis of 1,3-diazetidin-2-ones (aza-β-lactams) as rationally designed transpeptidase and β-lactamase inhibitors | |
| dc.type | Journal. Article | |
| dspace.entity.type |
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