Ca(II)-catalyzed diastereoselective formal [4+2] annulation of a 3-component solvent-free povarov reaction
Ca(II)-catalyzed diastereoselective formal [4+2] annulation of a 3-component solvent-free povarov reaction
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Date
2019-04-11
Authors
Khaja Mohinuddin, P. Md
Dada, Ravikrishna
Almansour, Abdulrahman I.
Arumugam, Natarajan
Yaragorla, Srinivasarao
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Abstract
Diastereoselective, three-component annulation reaction involving glyoxals, anilines and dienophiles is developed under calcium catalysis. When indene is the dienophile, the reaction gave excellent diastereoselectivity to yield tetrahydro-indenoquinolines, these were further aromatized to get indenoquinolines in one-pot. Aryl acetylenes are used as dienophiles to get 2-acyl quinolines in good yields.
Description
Keywords
Annulation reaction,
Calcium catalysis,
Diastereoselective,
Povarov reaction
Citation
Tetrahedron Letters. v.60(15)