Ca(II)-Catalyzed Regioselective Cascade Synthesis of Oxindolyl- Naphthofurans through Meyer-Schuster type Rearrangement

Abstract

Highly regioselective synthesis of 3-Oxindolyl naphthofurans has been described through an interesting Meyer-Schuster (M−S) type rearrangement followed by oxacyclisation using environmentally benign calcium salt. This synthetic protocol is ornamented with many of the green synthetic aspects such as solvent free, one pot cascade, -atom economy, step economy and the use of calcium salt which is highly abundant in the nature. The selected compounds were tested for their preliminary anti-amyloidogenic properties to highlight the importance of such compounds and methodologies.