Baylis-Hillman acetates in organic synthesis: A simple two-step strategy for oxindole-spiro-α-arylidene-γ-butyrolactone framework
Baylis-Hillman acetates in organic synthesis: A simple two-step strategy for oxindole-spiro-α-arylidene-γ-butyrolactone framework
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Date
2018-05-10
Authors
Basavaiah, Deevi
Lingam, Harathi
Babu, Thelagathoti Hari
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Abstract
A facile, convenient, and two step strategy for synthesis of spirooxindoles containing α-arylidene-γ-butyrolactone moiety has been developed via monoalkylation of 2-oxindoles with Baylis-Hillman acetates followed by the spirolactonization of the resulting cinnamic esters on treatment with phenyliodine (III) bistrifluoroacetate (PIFA).
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Keywords
Baylis-Hillman reaction,
PIFA,
Spirolactonization,
Spirooxindole,
γ-Butyrolactone
Citation
Tetrahedron. v.74(19)