Less reactive ketones as electrophiles and acrylamides as activated alkenes in intramolecular Baylis-Hillman reaction: Facile synthesis of functionalized γ-lactam frameworks
Less reactive ketones as electrophiles and acrylamides as activated alkenes in intramolecular Baylis-Hillman reaction: Facile synthesis of functionalized γ-lactam frameworks
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Date
2014-10-28
Authors
Basavaiah, Deevi
Reddy, Guddeti Chandrashekar
Bharadwaj, Kishor Chandra
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Abstract
Less reactive ketones and acrylamides have been successfully employed as electrophiles and activated alkenes, respectively, in intramolecular Baylis-Hillman reaction, thus providing a facile protocol for obtaining functionalized α-methylene-γ-lactam derivatives.
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Keywords
Acrylamide ketones,
Baylis-Hillman reaction,
DABCO,
Lactam,
Nitrogen heterocycles
Citation
Tetrahedron. v.70(43)