The Baylis-Hillman acetates in organic synthesis: Development of a facile strategy for synthesis of functionalized unsaturated benzo-fused macrocyclic ethers and [n] metacyclophanes

Abstract

A general synthetic protocol for obtaining functionalized unsaturated benzo-fused macrocyclic ethers and [n] metacyclophanes containing 13-, 14-, 15-, 16- and 20-membered rings has been developed using Baylis-Hillman (BH) acetates as starting materials and ring closing metathesis as a key step. © 2013 The Royal Society of Chemistry.