Baylis-Hillman acetates in carbocyclic synthesis: A convenient protocol for synthesis of densely substituted indenes
Baylis-Hillman acetates in carbocyclic synthesis: A convenient protocol for synthesis of densely substituted indenes
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Date
2013-02-25
Authors
Basavaiah, Deevi
Reddy, Bhavanam Sekhara
Lingam, Harathi
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Abstract
A simple and facile strategy for synthesis of densely substituted indenes have been developed from Baylis-Hillman acetates in a two step protocol, that is, (1) via treatment with DABCO and then reaction with alkyl 3-oxobutanoates in the presence of K2CO3 (2) followed by the intramolecular Friedel-Crafts cyclization of the resulting keto-diesters using titanium tetrachloride. © 2013 Elsevier Ltd. All rights reserved.
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Keywords
Baylis-Hillman reaction,
Chemo selectivity,
Friedel-Crafts reaction,
Indene derivatives,
Keto-diesters
Citation
Tetrahedron. v.69(8)