Applications of Baylis-Hillman acetates: One-pot, facile and convenient synthesis of substituted γ-lactams
Applications of Baylis-Hillman acetates: One-pot, facile and convenient synthesis of substituted γ-lactams
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Date
2004-02-16
Authors
Basavaiah, Deevi
Rao, Jamjanam Srivardhana
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Abstract
A simple, convenient and one-pot transformation of the acetates of Baylis-Hillman adducts into substituted γ-lactams, that is, (E)-5-alkyl-3-arylidenepyrrolidin-2-ones via treatment with nitroalkanes in the presence of a base, followed by reductive cyclization, using Fe/AcOH, is described. © 2004 Elsevier Ltd. All rights reserved.
Description
Keywords
Baylis-Hillman chemistry,
Fe/AcOH,
Reductive cyclization,
γ-Lactams
Citation
Tetrahedron Letters. v.45(8)