Novel form v of tolbutamide and a high Z′ crystal structure of form III

Abstract

Attempted co-crystallization of tolbutamide with p-phenylenediboronic acid and p-nitrophenol in EtOH afforded a modulated high Z′ crystal structure of the known form III of tolbutamide instead of the anticipated co-crystals. A novel form V of tolbutamide was crystallized when a trace of conc. HNO 3 was added in MeOH solvent. © 2011 The Royal Society of Chemistry.