Stereoselective Insertion of Benzynes into Lawsones: Synthesis of Biologically Important Benzannulated Bicyclo[3.3.0]octanes
Stereoselective Insertion of Benzynes into Lawsones: Synthesis of Biologically Important Benzannulated Bicyclo[3.3.0]octanes
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Date
2019-01-24
Authors
Kumar, A. Suresh
Thirupathi, Guguloth
Reddy, G. Surendra
Ramachary, Dhevalapally B.
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Abstract
An ideal stereoselective insertion of in situ generated benzynes into lawsones through domino formal [2+2]-cycloaddition followed by rearrangement is disclosed. The reaction allowed for the preparation of biologically important benzannulated bicyclo[3.3.0]octanes in good yields and with excellent selectivities by using simple substrates and conditions.
Description
Keywords
arynes,
bicyclo[3.3.0]octanes,
catalysis,
lawsones,
[3+2]-cycloaddition
Citation
Chemistry - A European Journal. v.25(5)