An Aldehyde-Azomethine Imine [3+2]-Cycloaddition: High-Yielding Regioselective Synthesis of Substituted N,N-Bicyclic Pyrazolidinones
An Aldehyde-Azomethine Imine [3+2]-Cycloaddition: High-Yielding Regioselective Synthesis of Substituted N,N-Bicyclic Pyrazolidinones
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Date
2018-07-23
Authors
Gujral, Jagjeet
Reddy, T. Prabhakar
Gorachand, B.
Ramachary, Dhevalapally B.
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Journal ISSN
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Abstract
An enolate mediated aldehyde-azomethine imine [3+2] cycloaddition of various aldehydes with N,N-cyclic azomethine imines is reported under DBU or tBuOK-catalysis. High reaction rate, ease of operation, simple catalyst, easily accessible starting materials and a wide substrate scope with numerous applications make this reaction an ideal addition to the click chemistry.
Description
Keywords
acetaldehydes,
azomethine imines,
click reaction,
N,N-bicyclic pyrazolidinones,
[3+2]-cycloaddition
Citation
ChemistrySelect. v.3(27)