Organocatalytic Asymmetric Formal [3+2] Cycloaddition as a Versatile Platform to Access Methanobenzo[7]annulenes
Organocatalytic Asymmetric Formal [3+2] Cycloaddition as a Versatile Platform to Access Methanobenzo[7]annulenes
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Date
2017-10-09
Authors
Ramachary, Dhevalapally B.
Anif Pasha, Mohammed
Thirupathi, Guguloth
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Abstract
Pharmaceutically and structurally important methanobenzo[7]annulenes were synthesized in very good yields with excellent enantio- and diastereoselectivities through an unprecedented organocatalytic formal [3+2] cycloaddition from readily available 2-alkyl-3-hydroxynaphthalene-1,4-diones and alkyl vinyl ketones.
Description
Keywords
cycloaddition,
heterocycles,
hydrogen bonds,
ketones,
organocatalysis
Citation
Angewandte Chemie - International Edition. v.56(42)