Azide-acetonitrile "click" reaction triggered by Cs < inf > 2 < /inf > CO < inf > 3 < /inf > : The atom-economic, high-yielding synthesis of 5-amino-1,2,3-triazoles

Abstract

Medicinally important 5-amino-1,2,3-triazoles were synthesized using a novel Cs2CO3-catalyzed azide-acetonitrile[3 + 2]-cycloaddition. Aryl azides and aryl acetonitriles were employed in this transformation resulting in excellent yields with high regioselectivity.