Discovery of 2-aminobuta-1,3-enynes in asymmetric organocascade catalysis: Construction of drug-like spirocyclic cyclohexanes having five to six contiguous stereocenters

Abstract

We present herein for the first time the asymmetric synthesis of drug-like spiranes through reflexive-Michael reaction by using 2-aminobuta-1,3-enyne catalysis under mild conditions. © 2012 Royal Society of Chemistry.