Synthesis and Utility of α-Methoxy Phosphonates with a 1,3,2-Dioxaphosphorinane Ring

Abstract

Synthesis of several α-methoxy phosphonates with the phosphorus as a part of 1,3,2-dioxaphosphorinane ring by the simple reaction of (OCH 2CMe2CH2O)PCl with acetals is described. Analogous methoxy phosphonates using (±) (C20H 12O2)PCl were also synthesized using the same route. Utility of these phosphonates in the synthesis of vinyl ethers via the Horner-Wadsworth-Emmons [HWE] reaction is demonstrated.