Effect in vitro of benthiocarb on rat brain succinate dehydrogenase

Abstract

Kinetic study of succinate dehydrogenase (SDH) was studied in the brain of albino rat to elucidate the interaction of benthiocarb, an organocarbamate with oxidative metabolism. The significant decrease in maximal velocity (Vmax) without appreciable change in Michaelis-Menten constant (Km) indicates that benthiocarb did not affect or interfere with succinate oriented sites on the enzyme and the inhibition is of a classical non-competitive type.