Biosynthesis of prostaglandins in ovarian follicles and corpus luteum of sheep ovary

Abstract

The biosynthetic potential of prostaglandins (PGs) was measured in ovarian follicles and corpus luteum of sheep ovary. The total prostaglandins formed under non-enzymatic conditions were much lower in comparison to that formed using native GSTs. When the GSTs of ovarian follicles were employed, the major prostaglandin formed was PGE2 (81.22%) followed by PGD2 (16.91%) and PGF2α (1.87%). In case of corpus luteum, prostaglandin formed was PGF2α (59.01%). Since PGF2α was demonstrated to be the luteolytic factor, the present study indicates the formation of luteolytic factor in the ovarian tissue itself.