The organophosphate degradation (opd) island-borne esterase-induced metabolic diversion in Escherichia coli and its influence on p-nitrophenol degradation
The organophosphate degradation (opd) island-borne esterase-induced metabolic diversion in Escherichia coli and its influence on p-nitrophenol degradation
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Date
2015-12-11
Authors
Chakka, Deviprasanna
Gudla, Ramurthy
Madikonda, Ashok Kumar
Pandeeti, Emmanuel Vijay Paul
Parthasarathy, Sunil
Nandavaram, Aparna
Siddavattam, Dayananda
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Abstract
Background: Because of the mobile nature of the opd island, identical opd and orf306 sequences are found among soil bacteria. Results: In E. coli, Orf306 suppresses glycolysis and the TCA cycle and promotes up-regulation of alternate carbon catabolic operons. Conclusion: The up-regulated hca and mhp operons contribute to PNP-dependent growth of E. coli. Significance: Together with opd, orf306 contributes to the complete mineralization of OP residues.
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Journal of Biological Chemistry. v.290(50)