Design, synthesis and characterization of 1H-pyridin-4-yl-3,5- disubstituted indazoles and their AKT inhibition activity

Abstract

A new series of 1H-pyridin-4-yl-3,5-disubstituted indazoles and their derivatives were synthesized by the reaction of 5-bromo-1-(2-cyano-pyridin-4-yl) -1H-indazole-3-carboxylic acid diethylamide with aryl boronic acids by Suzuki coupling reaction in the presence of Pd(OAc)2 and CsF. All the new compounds have been characterized by spectral data. The title compounds were subsequently evaluated for their Akt kinase activity. © 2014 Indian Academy of Sciences.