Facile development of superparamagnetic nanoparticle encapsulated protein based nanocarrier for targeted drug delivery application

Abstract

In this work, facile development of superparamagnetic Fe 3 O 4 nanoparticle encapsulated bovine serum albumin (BSA) based nanocarrier (Fe 3 O 4 @BSA) for targeted drug delivery application has been reported. First, highly monodisperse and well crystalline superparamagnetic Fe 3 O 4 nanoparticle was prepared and then a green and simple sonochemical method was used for the development of Fe 3 O 4 @BSA nanocarrier. The structural, morphological, and magnetic properties of the prepared Fe 3 O 4 @BSA nanocarrier have been studied by XRD, TEM, SAED, FTIR and VSM techniques. The particle sizes of Fe 3 O 4 nanoparticle and Fe 3 O 4 @BSA nanocarrier were found to be 5-10 nm and 50-300 nm respectively. TEM micrographs and FTIR analysis confirmed the successful coating of amorphous BSA on crystalline Fe 3 O 4 NPs. Magnetic measurement revealed the superparamagnetic nature of the prepared Fe 3 O 4 @BSA nanocarrier. Fe 3 O 4 @BSA nanocarrier with smaller particle sizes, good physical and chemical stability, excellent water dispersability and low toxicity could have potential for targeted drug delivery applications.