Regeneration of lacrimal gland: Potential and progress

Abstract

Dry eye syndrome (DES) is a chronic debilitating condition with high incidence of ocular morbidity. The most common factors associated with the development of DES are low androgen pool, autoimmune diseases, contact lens wear, orbital radiation therapy, etc. The current management of the disease aims at lubricating and hydrating the ocular surface, which provide short-term palliative relief to the patients without arresting/reversing the progression of the condition. This chapter reviews the option of cell therapy with secretory competent ex vivo expanded cells or pharmacologically recruited in situ stem cells that can be explored to repair/regenerate the damaged gland, provide long-term relief to these patients, and improve their quality of life.