Antibodies against the cytoplasmic tail can differentiate between the quaternary forms of the M < inf > r < /inf > 46000 mannose 6-phosphate receptor

Abstract

An antiserum against a peptide of the cytoplasmic tail of the Mr 46000 mannose 6-phosphate receptor is described which recognizes preferentially the tetrameric versus the dimeric form of this receptor. This indicates that the conformation of the cytoplasmic tail, which harbours signals necessary for the trafficking of the receptor, depends on the quaternary structure of the receptor. © 1991.