ClosIndb: A resource for computationally derived information from clostridial genomes

Abstract

Over the past few years, several clostridial genomes have been sequenced, and since then new sequencing projects are also under way. Clostridia is one of the most sequenced genera, and presently, complete genome sequences of 49 clostridial species are available in public archives. Unraveling this wealth of genomic information opens up potential avenues in clostridial research. In the present study, we have carried out in silico analysis to decipher the genomic data. Subsequently, a web resource, ClosIndb, has been developed which collates the computationally derived information associated with all clostridial genes. It features various aspects of coding regions as well as non-coding regions, such as putative orthologs, proteins physicochemical properties, operons and cis-regulatory elements. It provides users with comparative details of all clostridial proteins across the firmicutes. ClosIndb is a comprehensive resource for all completely sequenced clostridial genomes and is under constant development. ClosIndb is freely accessible at http://bif.uohyd.ac.in/closindb/.