New, convenient methods of synthesis and resolution of 1,2-amino alcohols
New, convenient methods of synthesis and resolution of 1,2-amino alcohols
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Date
2003-01-01
Authors
Periasamy, Mariappan
Sivakumar, Sangarappan
Reddy, Meda Narsi
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Abstract
Oximes of α-keto esters are reduced to obtain the corresponding amino alcohols using NaBH4 in combination with I2, CH 3COOH, TiCl4, ZrCl4, COCl2, H 2SO4, and TMS-Cl in 60-85% yields. The racemic phenylglycinol, phenylalaninol, and 2-aminobutanol are resolved using dibenzoyl-L-tartaric acid to obtain enantiomeric samples of > 98% ee.
Description
Keywords
Amino alcohols,
Boron,
Enantiomeric resolution,
Esters,
Oximes
Citation
Synthesis