A novel curcumin-artemisinin coamorphous solid: Physical properties and pharmacokinetic profile
A novel curcumin-artemisinin coamorphous solid: Physical properties and pharmacokinetic profile
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Date
2014-01-01
Authors
Suresh, Kuthuru
Chaitanya Mannava, M. K.C.
Nangia, Ashwini
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Abstract
Here we report a curcumin-artemisinin coamorphous solid (1:1) prepared by rotavaporization and a dramatic increase in the pharmacokinetic profile of curcumin (AUC0-12 2.6 μg h mL-1, Cmax 1 μg mL-1) administered as CUR-ART to SD rats. PXRD and FESEM analysis explains the molecular basis for the solubility enhancement of coamorphous CUR-ART.
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RSC Advances. v.4(102)