Development and Molecular Characterization of Novel HIV-1 Associated Topoisomerase II β Kinase Inhibitors during HIV-1 Replication

Abstract

HIV-1(Human Immunodeficiency Virus-1) belongs to genus lenti virus, family retroviridaeand subfamily orthoretrovirinae(1).HIV frequently associated with Acquired Immune Deficiency Syndrome (AIDS), a paradigmin humans where the immune organization fails and finally takes to the high-risk opportunistic infectionsin the life(35). According to the WHO/UNAIDS, globally37.9 million peoplewere infected with HIV-1/AIDS,in which adults were 36.2 million and children were1.7 million. Worldwide an estimation of newly infected people with HIV-1 were1.7 millionand 32.0 million people have died from AIDS-related illnesses(23.6 million–43.8 million) since from the beginning of this epidemic disease(59). India is the third largest country in having the HIV infected cases when compared with the world’s epidemiology. HIV/AIDS prevalence rate in India is lower than in many other countries, the epidemic status in India is having an estimation of 0.30%in HIV-1prevalence, in which adults are aged between 15-49 years and children are below 15 years (59).