New methods of resolution and purification of racemic and diastereomeric amino alcohol derivatives using boric acid and chiral 1,1′-bi-2-naphthol

Abstract

Resolution of the racemic amino alcohol derivatives 1-6 is readily achieved to obtain enantiomerically enriched compounds using chiral 1,1′-bi-2-naphthol and boric acid in solvents such as CH3-CN, THF, and MeOH. Purification of the diastereomeric mixture 7 has also been carried out following this method. The corresponding intermediate ammonium borate complexes were also characterized by X-ray diffraction methods.