New potent cytotoxic lamellarin alkaloids from Indian ascidian Didemnum obscurum
New potent cytotoxic lamellarin alkaloids from Indian ascidian Didemnum obscurum
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Date
2005-09-26
Authors
Reddy, S. Malla
Srinivasulu, M.
Satyanarayana, N.
Kondapi, Anand K.
Venkateswarlu, Y.
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Abstract
Chemical investigations of the ascidian Didemnum obscurum has resulted in the isolation of four new lamellarin alkaloids, lamellarin-ζ (1), lamellarin-η (2), lamellarin-φ (3) and lamellarin-χ (4) along with seven known lamellarins, lamellarin-K (5), lamellarin-I (6), lamellarin-J (7), lamellarin-K triacetate (8), lamellarin-L triacetate (9), lamellarin-F (10) and lamellarin-T diacetate (11). The structures of the compounds 1-11 were established by detailed analysis of NMR spectral data. Cytotoxic activity of the isolates has been done against coloractal cancer cells. © 2005 Elsevier Ltd. All rights reserved.
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Keywords
Ascidians,
Coloractal cancer cells,
Cytotoxic activity,
Lamellarin alkaloids
Citation
Tetrahedron. v.61(39)