Solvent effect on copper-catalyzed azide-alkyne cycloaddition (CuAAC): Synthesis of novel triazolyl substituted quinolines as potential anticancer agents
Solvent effect on copper-catalyzed azide-alkyne cycloaddition (CuAAC): Synthesis of novel triazolyl substituted quinolines as potential anticancer agents
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Date
2012-05-15
Authors
Ellanki, Amarender Reddy
Islam, Aminul
Rama, Veera Swamy
Pulipati, Ranga Prasad
Rambabu, D.
Rama Krishna, G.
Malla Reddy, C.
Mukkanti, K.
Vanaja, G. R.
Kalle, Arunasree M.
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Abstract
A regioselective route to novel mono triazolyl substituted quinolines has been developed via copper-catalyzed azide-alkyne cycloaddition (CuAAC) of 2,4-diazidoquinoline with terminal alkynes in DMF. The reaction provided bis triazolyl substituted quinolines when performed in water in the presence of Et 3N. A number of the compounds synthesized showed promising anti-proliferative properties when tested in vitro especially against breast cancer cells. © 2012 Elsevier Ltd. All rights reserved.
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Keywords
Alkyne,
Azide,
Cancer,
Click chemistry,
Quinoline
Citation
Bioorganic and Medicinal Chemistry Letters. v.22(10)