Solvent effect on copper-catalyzed azide-alkyne cycloaddition (CuAAC): Synthesis of novel triazolyl substituted quinolines as potential anticancer agents
Solvent effect on copper-catalyzed azide-alkyne cycloaddition (CuAAC): Synthesis of novel triazolyl substituted quinolines as potential anticancer agents
| dc.contributor.author | Ellanki, Amarender Reddy | |
| dc.contributor.author | Islam, Aminul | |
| dc.contributor.author | Rama, Veera Swamy | |
| dc.contributor.author | Pulipati, Ranga Prasad | |
| dc.contributor.author | Rambabu, D. | |
| dc.contributor.author | Rama Krishna, G. | |
| dc.contributor.author | Malla Reddy, C. | |
| dc.contributor.author | Mukkanti, K. | |
| dc.contributor.author | Vanaja, G. R. | |
| dc.contributor.author | Kalle, Arunasree M. | |
| dc.contributor.author | Shiva Kumar, K. | |
| dc.contributor.author | Pal, Manojit | |
| dc.date.accessioned | 2022-03-27T01:02:14Z | |
| dc.date.available | 2022-03-27T01:02:14Z | |
| dc.date.issued | 2012-05-15 | |
| dc.description.abstract | A regioselective route to novel mono triazolyl substituted quinolines has been developed via copper-catalyzed azide-alkyne cycloaddition (CuAAC) of 2,4-diazidoquinoline with terminal alkynes in DMF. The reaction provided bis triazolyl substituted quinolines when performed in water in the presence of Et 3N. A number of the compounds synthesized showed promising anti-proliferative properties when tested in vitro especially against breast cancer cells. © 2012 Elsevier Ltd. All rights reserved. | |
| dc.identifier.citation | Bioorganic and Medicinal Chemistry Letters. v.22(10) | |
| dc.identifier.issn | 0960894X | |
| dc.identifier.uri | 10.1016/j.bmcl.2012.03.091 | |
| dc.identifier.uri | https://www.sciencedirect.com/science/article/abs/pii/S0960894X12004210 | |
| dc.identifier.uri | https://dspace.uohyd.ac.in/handle/1/3941 | |
| dc.subject | Alkyne | |
| dc.subject | Azide | |
| dc.subject | Cancer | |
| dc.subject | Click chemistry | |
| dc.subject | Quinoline | |
| dc.title | Solvent effect on copper-catalyzed azide-alkyne cycloaddition (CuAAC): Synthesis of novel triazolyl substituted quinolines as potential anticancer agents | |
| dc.type | Journal. Article | |
| dspace.entity.type |
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